Date: Wed, Jun 22, 2011 at 1:13 PM
Subject: Evidence on Anti-Snake-Venom
Subject: Evidence on Anti-Snake-Venom
To: EVIDENCE-BASED-HEALTH@
This could be naive and i would be glad to benefit from the advise of esteemed others who could guide me to a systematic review on the 'topic':
There is still something unsettling about the use of Anti-Snake-Venom which has historically never been subjected to placebo controlled trials(neither has been penicillin but it is no longer as much used as anti-snake venom).
Is it possible that it may not have much role at all (other than harm) from whatever historical evidence available? Most of the successes of snake bite management appears to be due to supportive management like dialysis and ventilation. People have brought down the dose of ASV by 50 to 70% in controlled trials and the effect appears same. http://www.ncbi.nlm.nih.gov/
This could be naive and i would be glad to benefit from the advise of esteemed others who could guide me to a systematic review on the 'topic':
There is still something unsettling about the use of Anti-Snake-Venom which has historically never been subjected to placebo controlled trials(neither has been penicillin but it is no longer as much used as anti-snake venom).
Is it possible that it may not have much role at all (other than harm) from whatever historical evidence available? Most of the successes of snake bite management appears to be due to supportive management like dialysis and ventilation. People have brought down the dose of ASV by 50 to 70% in controlled trials and the effect appears same. http://www.ncbi.nlm.nih.gov/
The
above are trials based in India. Is it possible that the low dose
anti-venom can be gradually in subsequent trials brought down to zero?
Would be good to learn if anyone has looked into other similar trials
elsewhere. Again apologize for any 'naivete' in this ( perhaps not well
though out) query.
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